张全云, 丁月东, 汪允珍, 赵保建, 曾永恒, 陈前芬. 氯胺酮对兔全脑缺血再灌注损伤血流动力学的影响[J]. 蚌埠医学院学报, 2013, 37(2): 129-130;133.
    引用本文: 张全云, 丁月东, 汪允珍, 赵保建, 曾永恒, 陈前芬. 氯胺酮对兔全脑缺血再灌注损伤血流动力学的影响[J]. 蚌埠医学院学报, 2013, 37(2): 129-130;133.
    ZHANG Quan-yun, DING Yue-dong, WANG Yun-zhen, ZHAO Bao-jian, ZENG Yong-heng, CHEN Qian-fen. The effect of ketamine on haemodynamics in global cerebral ischemia reperfusion injury of rabbits[J]. Journal of Bengbu Medical College, 2013, 37(2): 129-130;133.
    Citation: ZHANG Quan-yun, DING Yue-dong, WANG Yun-zhen, ZHAO Bao-jian, ZENG Yong-heng, CHEN Qian-fen. The effect of ketamine on haemodynamics in global cerebral ischemia reperfusion injury of rabbits[J]. Journal of Bengbu Medical College, 2013, 37(2): 129-130;133.

    氯胺酮对兔全脑缺血再灌注损伤血流动力学的影响

    The effect of ketamine on haemodynamics in global cerebral ischemia reperfusion injury of rabbits

    • 摘要: 目的:探讨氯胺酮对兔全脑缺血再灌注损伤血流动力学的影响。方法:新西兰大耳白兔15只,随机分为对照组(A组)、模型组(B组)、氯胺酮组(C组),B、C组采用两血管结扎加股动脉放血法制备全脑缺血模型,C组于夹毕双侧颈总动脉后经股静脉匀速静注氯胺酮,术中监测脑电图(EEG)、心电图(ECG)、平均动脉压(MAP)、心率(HR)。结果:B、C组HR在缺血30 min均较A组显著增快(P0.01);B组动物在再灌注30 min HR明显低于A组(P0.01),B组MAP在缺血30 min均较A、C组显著降低(P0.01),恢复再灌注30 min后增高,但仍低于基础值(P0.01);C组EEG在缺血30 min及再灌注30 min后均较A、B组显著增高(P0.01)。C组缺血30 min内HR显著高于B组(P0.01),而C组再灌注30 min HR明显高于B组(P0.01)。结论:氯胺酮能较好地维持兔全脑缺血再灌注期间血流动力学稳定,可有效减轻全脑缺血再灌注导致的脑损伤。

       

      Abstract: Objective:To investigate the effects of ketamine on haemodynamics in global cerebral ischemia reperfusion injury of rabbits.Methods:Fifteen adult healthy New Zealand white rabbits were randomly divided into control group(group A),model group(group B) and ketamine group(group C).The global cerebral ischemia reperfusion model of group B and C was established by two-vessel occlusion combined with femoral arterial bloodletting.The rabbits in group C were injected with ketamine by femoral vein after nipping bilateral common carotid arteries,and electroencephalogram(EEG),electrocardiogram(ECG),mean arterial blood pressure(MAP) and heart rate(HR) were monitored during operation.Results:Compared with group A,the HR of group B and C sped significantly up at 30 minutes after ischemia(P0.01),and the HR of group B was significantly lower than that in group A(P0.01) at 30 min after reperfusion.The MAP of group B were significantly lower than that in group A and C(P0.01) at 30 min after ischemia,and began to rise at 30 mins after reperfusion and was still less than basic value(P0.01).The EEG of group C was significantly higher than that in group A and B at 30 mins after ischemia and reperfusion(P0.01).The HR of group C was significantly higher than that in group B at 30 min after ischemia(P0.01),and HR at 30 mins after reperfusion of group C were significantly higher than that in group B(P0.01).Conclusions:Ketamine can maintain the haemodynamic stability of rabbit global cerebral ischemia reperfusion injury,which can effectively alleviate and reduce brain injury caused by ischemia reperfusion.

       

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