Abstract: Objective: To investigate the efficacy and anti-inflammatory mechanism of atorvastatin in treatment of diabetic nephropathy.Methods: Sixty four cases of diabetic nephropathy(DN) in our hospital were randomly divided into treatment group 35 cases and control group 29 cases.The control group were only administered the conventional therapy(ACEI or ARB),and the treatment group were given atorvastatin 40 mg,once a day in addition to the routine therapy.The plasma C-reactive protein(CRP),urinary albumin excretion rate(UAER),plasma creatinine(SCr),and other indicators were compared between the two groups six months after treatment.Results: Atorvastatin significant decreased the CRP,SCr and UAER in the patients with diabetic nephropathy(P<0.01).Conclusions: Atorvastatin may obviously reduce the UAER and the inflammatory response of DN,and improve the renal function of the patients with diabetic nephropathy.