The clinical significance of the serum levels of vascular endothelial growth factor and carbohydrate antigen 199 in patients with gastric cancer before and after chemotherapy
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摘要: 目的:探讨胃癌患者化疗前后血清血管内皮生长因子(VEGF)、糖抗原(CA)199水平的变化及临床意义。方法:应用ELISA方法检测40例胃癌患者(胃癌组)血清VEGF、CA199水平,并与40名正常健康人(对照组)作比较。结果:胃癌患者化疗前血清VEGF、CA199水平均显著高于正常对照组(P0.01)。化疗8周后,完全缓解+部分缓解组治疗后VEGF、CA199水平均较治疗前明显降低(P0.01);稳定组治疗后VEGF水平变化差异无统计学意义(P0.05),CA199较治疗前降低(P0.01);进展组治疗后2项指标水平均较治疗前升高(P0.01),且治疗前2项指标呈正相关关系(P0.01)。结论:测定胃癌患者血清中VEGF、CA199水平的变化对早期诊断和对评价患者的治疗效果具有重要的临床价值。Abstract: Objective:To investigate the significances of the serum level changes of vascular endothelial growth factor(VEGF) and carbohydrate antigen 199(CA199) in patients with gastric cancer before and after chemotherapy.Methods:The serum levels of VEGF and CA199 of 40 cases with gastric cancer were measured by ELISA,and which were compared with those in forty healthy people.Results:The serum levels of VEGF and CA199 in gastric carcinoma patients were significantly higher than those in the healthy people before chemotherapy(P0.01),but the serum levels in complete remission and partial remission patients in 8 weeks post-chemotherapy were significantly lower than those in pre-chemotherapy(P0.01).The VEGF levels in the stable treatment patients had no statistical significance(P0.05),and the CA199 levels were lower than that of before chemotherapy(P0.01).The serum levels of VEGF and CA199 in the progress group were higher than those of before treatment and existed the positive correlation(P0.01).Conclusions:The serum levels of VEGF and CA199 in patients with gastric cancer are important parameters for early diagnosis and evaluating treatment effects.
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[1] [2] 王友春,马建党,韩宏锋,等.胃癌化疗前后循环血浆VEGF、1L-8变化的临床意义[J].胃肠病学和肝病学杂志,2008,17 (3):226-227. [1] Ajani,J A.Evolving chemotlierapy for advanced gastric cancer[J].Oncologist, 2005,10 (3):4958.
[2] [3] 倪效,燕敏. VEGF'受体功能研究进展[J].生命科学,2008,20 (1):120-124. [3] [4] 石海,许建明.COX-2、VEGF在胃癌中的表达及其预后意义[J].中国癌症杂志,2003,13 (6):518-522. [4] [5] Liu LY, Han YC, Wu SH, et al. Expression of connective tissuegrowth factor in tumor is an independent predictor of poor prognosisin patients with gastric cancer[J].World,J Gastroentero1,2008,14(13):21102114.
[5] [6] 何家才,阮敏,王元银,等.血管内皮生长因子和微血管密度在口腔鳞癌中的表达[J].安徽医科大学学报,2006,41 (1):41-43. [6] [7] 薛洪燕,陈丽荣.子宫颈鳞状细胞癌VEGF-C及其受体、vEGFR_3的表达及其临床意义[J].实用肿瘤杂志,2008,23 (1):24-27. [7] [8] 彭莉,朱传金,刘玉红,等.血清CL,A. CA19-9. CA242联检在大肠癌诊断及随访中的临床应用[J].放射免疫学杂志,2006,19 (3):239241. [8] [1] Gondon NS, Hadlow G, Knight E et al. Transurethral resection of the prostate:still the gold standard[J].Aust N Z Surg, 1997 67 (6):354357.
[9] [2] Alivizatos G, Skolarikos A. Greenlight laser in benign prostatic hyperplasia:turning green into gold[J].Curr Opin Lro1,2008,18 (1):4649.
[10] [3] Van CB, Srirangam SJ, Van P11. High-Performance system Greenlight laser: indications and outcomes[J].Curr Opin Lrol, 2009,19(1):33-37.
[11] [4] Malek RS, Nahen K. Laser treatment of obstructive BPH: Problems and progress[J].Contemp Crol, 2004, 16 (5):37- 43.
[12] [13] [5] Barber NJ, Muir GH. High-Power KTP laser prostatectomy: the new challenge to transurethral resection of the prostate[J].Curr Opin Cro1,2004,14(1):21-25.
[14] [6] Sohn JH, Choi YS, Kim SJ, et al. L,ffectiveness and safety of photoselective vaporization of the prostate with the 120 W HPS greenlight laser in benign prostatic hyperplasia patients taking oral anticoagulants[J].Korean J Croh 2011, 52 (3):178183.
[15] [7] 张琦,王慕文,赵勇.术前口服非那雄胺及留置导尿管对光选 择性前列腺汽化术有无影响的研究[J].泌尿外科杂志:电子 版,2011,3 (1):3134. [16] [17] [8] 熊玮,冉清,窦科,等.经尿道选择性绿激光汽化术治疗大体 积良性前列腺增生症[J].华西医学,2010, 25 (9): 1615- 1617. [18] [9] 梁伟东,白亮,钟羽翔,等.经尿道前列腺电切术(TURP)患者 PS A变化的临床研究[J].遵义医学院学报,2008, 31 (2) 132133. [19] [10] 中长发,刘辉,金讯波,等.经尿道选择性绿激光前列腺汽化 术治疗巨大前列腺增生症[J].山东大学学报:医学版,2008, 64 (12):12071208.
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