胃癌化疗前后血清血管内皮生长因子和糖抗原199水平的变化及其临床意义
The clinical significance of the serum levels of vascular endothelial growth factor and carbohydrate antigen 199 in patients with gastric cancer before and after chemotherapy
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摘要: 目的:探讨胃癌患者化疗前后血清血管内皮生长因子(VEGF)、糖抗原(CA)199水平的变化及临床意义。方法:应用ELISA方法检测40例胃癌患者(胃癌组)血清VEGF、CA199水平,并与40名正常健康人(对照组)作比较。结果:胃癌患者化疗前血清VEGF、CA199水平均显著高于正常对照组(P0.01)。化疗8周后,完全缓解+部分缓解组治疗后VEGF、CA199水平均较治疗前明显降低(P0.01);稳定组治疗后VEGF水平变化差异无统计学意义(P0.05),CA199较治疗前降低(P0.01);进展组治疗后2项指标水平均较治疗前升高(P0.01),且治疗前2项指标呈正相关关系(P0.01)。结论:测定胃癌患者血清中VEGF、CA199水平的变化对早期诊断和对评价患者的治疗效果具有重要的临床价值。Abstract: Objective:To investigate the significances of the serum level changes of vascular endothelial growth factor(VEGF) and carbohydrate antigen 199(CA199) in patients with gastric cancer before and after chemotherapy.Methods:The serum levels of VEGF and CA199 of 40 cases with gastric cancer were measured by ELISA,and which were compared with those in forty healthy people.Results:The serum levels of VEGF and CA199 in gastric carcinoma patients were significantly higher than those in the healthy people before chemotherapy(P0.01),but the serum levels in complete remission and partial remission patients in 8 weeks post-chemotherapy were significantly lower than those in pre-chemotherapy(P0.01).The VEGF levels in the stable treatment patients had no statistical significance(P0.05),and the CA199 levels were lower than that of before chemotherapy(P0.01).The serum levels of VEGF and CA199 in the progress group were higher than those of before treatment and existed the positive correlation(P0.01).Conclusions:The serum levels of VEGF and CA199 in patients with gastric cancer are important parameters for early diagnosis and evaluating treatment effects.
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