高浓度葡萄糖对兔十二指肠自律性的影响

Effects of high glucose concentrations on the auto-rhythmicity of the smooth muscle of duodenum of rabbits

摘要: 目的: 观察高糖灌流对兔十二指肠平滑肌自律性的影响。方法: 取兔十二指肠段分别用正常台氏液和含糖量9.7 mmol/L、11.1 mmol/L台氏液灌流肠管,记录收缩曲线。结果: 与灌流前比较,加入9.7 mmol/L高糖台氏液10 min后,收缩幅度抑制最明显(P<0.05),然后逐渐回升。加入11.1 mmol/L的高糖台氏液20 min后,收缩幅度抑制最明显(P<0.05),然后也逐渐回升。结论: 高糖对肠道平滑肌自律性收缩的影响表现为先兴奋后抑制。

Abstract: Objective: To observe the effects of high concentration of glucose on the auto-rhythmicity of the smooth muscle of rabbit duodenum.Methods: Duodenum of rabbits were isolated and put into normal Tyrode solutions.Tyrode solutions coutaining high glucose(9.7 mmol/L and 11.1 mmol/L),and then the curve of contraction was recorded.Results: The contraction amplitude of the duodenum in Tyrode solution containing glucose concentrations 9.7 mmol/L was distinctly inhibited at 10 min(P<0.05),while that in Tyrode solution containing glucose of 11.1 mmol/L was distictly inhibited at 20 min(P<0.05);and then the contraction rose gradually.Conclusions: High concentration of glucose may make the contraction of duodenum inhibited.When the glucose concentrations in Tyrode solution increased,the time when the contraction of the duodenum was inhibited was prolonged.