慢性阻塞性肺疾病患者TH17细胞的表达及功能研究

    The expression and function of TH17 cells in chronic obstructive pulmonary disease

    • 摘要: 目的:探讨慢性阻塞性肺疾病(COPD)患者TH17细胞的表达及功能。方法:选取COPD稳定期患者30例作为COPD稳定期组,门诊不吸烟的健康体检者30名为正常对照组。通过流式细胞术检测外周血TH17细胞的表达,ELISA检测血浆中白介素(IL)-17、IL-4、干扰素(IFN)-水平。结果:外周血中TH17细胞比例COPD稳定期组要高于正常对照组(P0.01),ELISA检测表明,COPD稳定期组血浆中IL-17和IFN-水平均明显高于正常对照组(P0.01),2组血浆中IL-4水平差异无统计学意义(P0.05)。结论:TH17细胞在COPD中的表达增加,参与了COPD慢性炎症过程。

       

      Abstract: Objective:To observe the expression and function of TH17 cells in patients with chronic obstructive pulmonary disease(COPD).Methods:Thirty patients with COPD were as the stable COPD group,30 healthy donors were enrolled as control.The expression of plasma TH17 cells was determined by flow cytometry.The levels of plasma interleukin(IL)-17,IL-4 and interferon(IFN)- were measured by ELISA.Results:The expression of TH17 cells in stable COPD group was significantly higher than that in normal group(P〈0.05).ELISA assay showed that the levels of plasma IL-17 and IFN- in stable COPD group were significantly higher than those in normal group(P〈0.05).The level of plasma IL-4 between the two groups had may participate statistical difference(P〉0.05).Conclusions:The expression of TH17 cells is significantly increased in patients with COPD,it participated in the chronic inflammatory process of COPD.

       

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