胸内结节病18F-FPG PET/CT与支气管肺泡灌洗液检查相关性分析

    Correlation between 18F-FDG PET/CT scan and bronchoalveolar lavage fluid in patients with thoracic sarcoidosis

    • 摘要: 目的:了解胸内结节病18氟-脱氧葡萄糖正电子发射断层显像/计算机断层扫描(18F-FDG PET/CT)检查与支气管肺泡灌洗液检查(BALF)相关性,探讨结节病摄取18F-FDG机制。方法:19例病理确诊胸内结节病患者行18F-FDG PET/CT检查及BALF,检测CD4+/CD8+T细胞比值和血清血管紧张素转化酶(sACE)、肿瘤坏死因子-(TNF-)及可溶性白细胞介素-2受体(sIL-2R)含量,18F-FDG PET/CT用最大标准摄取值(SUVmax)和平均标准摄取值(SUVmean)半定量分析,并分别分析SUVmax和SUVmean与CD4+/CD8+T细胞比值和sACE、TNF-及sIL-2R含量相关性。结果:SUVmax和SUVmean之间有显著相关关系(P0.01);SUVmax与sACE及TNF-之间均有显著相关关系(P0.01);SUVmean与sACE及TNF-之间也均有显著相关关系(P0.01);SUVmean与CD4+/CD8+T之间有相关关系(P0.05)。结论:结节病肉芽肿负荷高者,摄取18F-FDG能力也高;其摄取18F-FDG能力可能与T细胞活化相关。SUVmean判定结节病活动性可能优于SUVmax。

       

      Abstract: Objective:To study the correlation between 18fluorine deoxyglucose(18F-FDG) positron emission tomography/computerized tomography(PET/CT) scan and bronchoalveolar lavage fluid(BALF)in patients with thoracic sarcoidosis,and explore the mechanism of 18F-FDG uptake in sarcoidosis.Methods:Nineteen patients with thoracic sarcoidosis underwent 18F-FDG PET/CT scan and BALF.The CD4+/CD8+ T cell ratio and serum angiotensin converting enzyme(sACE),tumor necrosis factor-(TNF-) and soluble interleukin-2 receptor(sIL-2R) levels in bronchoalveolar lavage fluid were detected.18F-FDG PET/CT scan was semi-quantitatively analyzed by maximum standardized uptake value(SUVmax) and mean standardized uptake value(SUVmean).The correlation between SUVmax,SUVmean,CD4+/CD8+ T cell ratio,sACE,TNF- and sIL-2R levels was also analyzed.Results:SUVmax was significantly correlated to SUVmean(P0.01).SUVmax was significantly correlated to sACE(P0.01) and TNF-(P0.01),respectively;SUVmean was also significantly correlated to sACE(P0.01) and TNF-(P0.01),respectively.SUVmean was correlated to CD4+/CD8+ T cell ratio(P0.05).Conclusions:The 18F-FDG uptake capacity is high in high load of sarcoidosis granuloma;its ability to 18F-FDG uptake may be associated with T cell activation.SUVmean may be superior to SUVmax in determining the activity of sarcoidosis.

       

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