Abstract: Objective：To sum up the clinical features of acute phosgene poisoning.Methods：Twenty three cases of acute phosgene poisoning in our hospital during Jan.6 to 8 in 2011were gathered.The latency phase,onset clinical manifestation,results of diagnosis and treatment were analyzed.Results：The latency phase in sever group was significantly shorter than in the other groups(mild group)(P〈0.01).The main onset clinical manifestations were cough(82.61%),oppressive sensation over the chest(69.57%).The respiratory rate,heart rat,levels of leukocyte count,neutrophil number,the value of creatine kinase,creatine phosphokinase-isoenzyme-MB and cardiac troponin-I in sever group was significantly greater than in the other groups(mild or moderately group)(P〈0.05 to P〈0.01).There were no deaths.Conclusions：The primary clinical symptom of acute phosgene poisoning mainly concentrated on the respiratory system.Each patient receives moderate-dose methylprednisolone and respiratory supporting according to the severity of the disease in the early stage,which is the key point for successful rescue.