Abstract: Objective:To investigate the value of color Doppler ultrasound in the diagnosis of triple negative breast cancer(TNBC).Methods:One hundred and sixty-nine cases of breast occupying lesions which were diagnosed by color Doppler ultrasound and confirmed as breast cancer by surgery and pathology were divided into TNBC groups(37 cases) and non-TNBC group(132 cases) according to the expression of estrogen receptor(ER),progesterone receptor(PR) and human epidermal growth factor receptor 2(HER2) determined by immunohistochemical staining.The ultrasonic image,pathological manifestation and clinical condition of the 2 groups were compared and analyzed.Results:Ultrasonic images showed that the TNBC group had a greater proportion in the masses with clear boundary and a smaller proportion in the masses with short burr on the edge than the non-TNBC group(P0.05);the TNBC group had lower echoes and less calcification than the non-TNBC group(P0.01),and its posterior sound shadow was less attenuated(P0.05);most of the masses in TNBC group showed no blood stream or little blood stream(P0.05);the proportion of flow resistance index0.7 in TNBC group was greater than that in non-TNBC group(P0.05).Pathological examinations showed that axillary lymph node metastases occurred more frequently in the TNBC group(P0.05).Conclusions:The above features make the mass more likely to be a benign one.The technique of color Doppler ultrasound is of use in the early diagnosis of TNBC.