Abstract: Objective:To explore the association of interpersonal relationship with family cohesion and adaptability among college students of nursing major.Methods:Two hundred and twenty-five nursing major freshmen and sophomores who scored no less than 9 on the interpersonal relationship scale were selected to fill out the social anxiety scale,the social avoidance and distress scale,and the family cohesion and adaptability scale.Results:No statistically significant differences were found across grades regarding interpersonal relationship,actual family cohesion,actual adaptability,ideal family cohesion and ideal adaptability(P0.05).However,there were significant gender differences in interpersonal relationship(P0.01).Interpersonal relationship was positively correlated with social anxiety,social avoidance,social distress,and the overall social avoidance and distress score(P0.01).Interpersonal relationship was negatively correlated with ideal family adaptability(P0.01).The scores on actual family cohesion and actual adaptability were lower than the norm(P0.01),and the scores in ideal family cohesion,ideal adaptability,the degree of dissatisfaction with cohesion(the difference between ideal and actual cohesion scores),the degree of dissatisfaction with adaptability(the difference between ideal and actual adaptability scores) were all higher than the norm(P0.01).Conclusions:The nursing major college students who have problems with interpersonal relationship show relatively low level of family cohesion and adaptability.Male students have more problems than the female,and those who have more problems show lower level of ideal family adaptability.Therefore,it is necessary to offer adequate family intervention to those who have difficulties in interpersonal relationship.