Abstract: Objective：To explore the effect of sufentail or flurbiprofen axetil combined with tramadol hydrochloride on patients in the recovery period after remifentanil-based general anesthesia.Methods：Forty patients undergoing laparoscopic cholecystectomy were evenly divided into two groups：sufentanil group(group A) and flurbiprofen axetil combined with tramadol hydrochloride group(group B).Group A received intravenous injection of 0.15 g/kg sufentanil five minutes before the end of the operation,and group B received intravenous injection of 50 mg flurbiprofen axetil ten minutes before the operation and 50 mg flurbiprofen axetil with 2 mg/kg tramadol hydrochloride ten minutes before the end of the operation.The recovery time,verbal rating scale and incidence of side effects were evaluated.Results：The recovery time of group A was longer than that of group B(P〈0.01).The VRS of group B at 10,20 and 30 min after extubation was significantly higher than that of group A(P〈0.01).The incidence of side effects was similar 2 h after extubation between the two groups(P〉0.05).Conclusions：Sufentanil provides more effective analgesia than flurbiprofen axetil combined with tramadol hydrochloride for patients in the early recovery period after remifentanil-based general anesthesia.