溶栓治疗后脑卒中患者应用他汀类药物疗效分析

The curative effects of statin on stroke patient with thrombolysis treatment

摘要: 目的:探讨在脑卒中患者经溶栓治疗后，他汀类药物的应用问题及其疗效。方法:服用或未服用他汀类药物的经溶栓治疗后脑卒中患者共9例，根据美国国立卫生院卒中量表(NIHSS)及改良Rankin评分(modified Rankin scale，mRS)评分来评价患者不同时期的脑功能恢复情况。结果:脑卒中急性期服用他汀者发病48 h NIHSS评分下降较未用他汀者明显(P0.01)，发病3个月mRS评分0～2分者4例，无病死病例(P0.01)。结论:在接受溶栓治疗的脑卒中患者中，他汀类药物在急性期的应用可促进发病后脑功能的恢复。

Abstract: Objective：To assess the curative effects of statin drugs on stroke patient with thrombolysis treatment.Methods：Brain function recovery condition of 9 stroke cases with thrombolysis treatment taking or no-taking statin was evaluated during different periods according to Modified Rankin scale(mRS) and Nationel Institutes of Health Stroke scale(NIHSS).Results：The NIHSS scores of cases who took statin were significantly lower than that of no-taking statin at 48 hours(P〈0.01).There were 4 cases mRS scores between 0-2 and no death with 3 months statin treatment.Conclusions：statin treatment can promote brain function recovery of stroke patient with thrombolysis treatment.