血清半胱氨酸蛋白酶抑制剂C在诊断糖尿病早期肾损害中的应用

The early application of serum cystatin C in diabetic sligt kidney damage

摘要: 目的:探讨血清半胱氨酸蛋白酶抑制剂C(Cys C)在诊断糖尿病早期轻微肾损害中的应用价值。方法:采用透射比浊法在Bayer ADVIA1800型自动生化分析仪上检测80例2型糖尿病患者(观察组)与35名健康成人(对照组)血清Cys C及血肌酐(Cr)的水平。针对糖尿病早期轻微肾损害时血清Cys C和血Cr的诊断敏感性予以比较分析。结果:2组Cys C差异有统计学意义(P0.01),而Cr差异无统计学意义(P0.05)。结论:糖尿病早期轻微肾损害时血清Cys C更敏感,在诊断糖尿病早期轻微肾损害时比Cr具有一定的优越性。

Abstract: Objective:To investigate the application value of serum cystatin C(Cys C) levels in the diagnosis of diabetic sligt kidney damage.Methods:The concentrations of serum Cys C and creatinine(Cr) in 80 cases with type 2 diabete(observation group)and in 35 healthy adults(control group) were detected through turbidimetric method by Bayer ADVIA1800 automatic biochemical analyzer.The diagnostic sensitivity of Cys C and Cr of diabetic sligt kidney damage were analyzed.Results:The levels of Cys C in observation and control group had significant difference(P0.01),but for Cr had no(P0.05).Conclusions:Serum Cys C is sensitive index in the diagnosis of early diabetic kidney damage,which has certain advantages than Cr.