地佐辛对颈丛阻滞下甲状腺手术患者术中应激反应的影响
Effects of dezocine on stree response in patientsundergoing thyroid surgery under cervical plexus block
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摘要: 目的：观察地佐辛对颈丛阻滞下甲状腺手术患者术中应激反应的影响。方法：将ASAⅠ～Ⅱ级行甲状腺手术患者40例随机均分为地佐辛组和对照组。麻醉前5min，2组分别静脉注射地佐辛0.1mg/kg和生理盐水，行患侧颈深丛和双侧颈浅丛神经阻滞。记录静脉给药前、切皮、术中及术毕时患者平均动脉压(MAP)、心率(HR)和脉搏氧饱和度(SpO2)值，检测静脉给药前、术中血糖(Glu)和血浆皮质醇(Cor)水平，观察麻醉效果，记录恶心呕吐、眩晕和呼吸抑制的发生率。结果：2组患者MAP和HR在切皮、术中及术毕较麻醉前明显上升(p0.05～p0.01)，但地佐辛组低于对照组(p0.05)。术中2组患者Glu和Cor水平均较麻醉前显著升高(p0.01)，但地佐辛组均低于对照组(p0.01)。地佐辛组麻醉效果明显优于对照组(p0.05)。2组患者各时点SpO2和术后不良反应发生率差异无统计学意义(P0.05)。结论：地佐辛能够较好地抑制颈丛麻醉下甲状腺手术患者术中应激反应。Abstract: To explore elfects of dezocine on stress response in patients with thyroid surgery under cervical plexus blockMethods: Forty ASAj or patients、. heduled for thyroid surgery by cervical plexus block were randomly divided into dezocine group(group D)and control group(group C). Croup D and group C were injected with dezocine 0. 1 mg/kg and normal saline respectivelyvia vein 5 mins before anesthesia. Then the sick side deep. ervical plexus and bilateral superficial cervical plexus were blocked.
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