Abstract: Objective:To study the etiology and clinical features of primary liver cancers(PLC).Methods:The age,gender,symptoms,liver function, fetoprotein(AFP) and imaging results of 177 patients with primary liver cancers were analyzed retrospectively.Results:The peak age of PLC was 40-60.The morbility of male and female was 3.43∶ 1.The infection rates of HBV and HCV were 75.14% and 0.56%,respectively.The positive rates of -glutamyl transferase(-GGT) and AFP were 73.45% and 74.58%,respectively.The rate of portal vein thrombosis and distant metastases were about 41.81% and 0.56%,respectively.Seventy-eight of the cases received surgical therapy.Among the 78 cases,68 were confirmed to be hepatocellular carcinoma(HCC) and 10 intrahepatic cholangiocarcinoma(ICC).The infection rate of HBV of the former(76.47%) was higher than that of the latter(10.00%)(P0.05);the positive rates of total bilirubin and alkaline phosphatase were 14.71% and 50.00% versus 17.65% and 60.00%(P0.05).Conclusions:The risk factors for PLC include ages above 40,male and infection of HBV.-GGT and AFP may be beneficial to the diagnosis of PLC.The most common metastasis of PLC is innerliver hematogenous metastasis.HCC is often observed in PLC.ICC patients usually have a high positive rate of alkaline phosphatase,which may be of help to the diagnosis of intrahepatic cholangiocarcinoma.