双歧杆菌三联活菌联合5-氨基水杨酸治疗溃疡性结肠炎的临床观察

The effects of double branch bacilli triplex viable bacteria combinedwith 5-aminosalicylic acid on ulcerative colitis

摘要: 目的：探讨双歧杆菌三联活菌联合5-氨基水杨酸对溃疡性结肠炎(UC)的临床疗效以及对血清白细胞介素-1(IL-1)和IL-4的影响。方法：将77例UC患者随机分为5-氨基水杨酸组38例(对照组)和5-氨基水杨酸联合双歧杆菌三联活菌治疗组39例(观察组)；治疗6周后，观察临床症状改变以及治疗前后两组血清中IL-1和IL-4的表达变化。结果：观察组总有效率高于改善情况明显优于对照组，表现为腹痛、腹泻、黏液脓血便症状好转或消失。观察组患者血清IL-1降低水平、血清IL-4升高水平与对照组(p0.05)，血清IL-4升高水平较对照组升高明显(p0.05)。结论：双歧杆菌三联活菌联合5-氨基水杨酸治疗UC疗效肯定，同时双歧三联活菌有助于逆转Th1和Th2细胞的失衡状态。

Abstract: To explore the effects of double branch bacilli triplex viable bacteria combined with 5 amino acid on ulcerative. olitis(UC)and the serum levels of ILK and ILK. Methods:Seventyeven cases with UC were randomly divided into 5 minosalicylicacid group(. ontrol group 38 cases)and 5 minosalicylic acid combined with double branch bacilli triplex viable bacteria group(observation group39 cases).