Abstract: Objective:To investigate the pathogeny of osteoporosis of patients with rheumatoid arthritis(RA),and the relationship between osteoporosis with severity of sickness.Methods:The bone density was determined by ultrasound.All cases were divided into osteoporosis and no-osteoporosis group.The anti-cyclic cicrullinated peptide(CCP) antibody was detected by enzyme linked immunosorbent assay for understanding the the relationship between osteoporosis with severity of sickness.Results:For osteoporosis group,the disease course was longer,and positive incidence of CCP and standard of RF was significantly higher than these of no-osteoporosis group(P0.05).But there were no significant difference in the age,sex,number of hurt and swollen articulation,erythrocyte sedimentation rate(ESR),C-reative protein(CRP) and parathyroid hormone(PTH) in the two groups(P0.05).Conclusions:It is very important for preserving capacity of labour and improving the patient survival qualities by examining bone density and early therapying osteoporosis of RA patients.