中国人群FGA、D5S818基因座的空间群体遗传结构分析
Spatially genetic structure analysis of FGA and D5S818 loci in Chinese nation
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摘要: 目的:分析中国87个人群常染色体FGA、D5S818基因座的空间群体遗传结构,为研究中华民族的起源、人口迁移、考古以及民族融合等群体遗传学和人类学问题提供分子生物学依据。方法:应用主成分分析的方法及GIS中的空间差值分析技术,从基因频率矩阵中提取综合指标,并采取可视化技术来反映中国人群2个短串联重复序列(STR)位点的空间群体遗传结构。结果:中国人群FGA、D5S818基因座的主成分空间分析结果划分出4大区域,显示出从东北向西南递增的趋势,同时在西北部也有增高趋势。结论:中国人群2个STR位点的空间群体遗传结构呈现明显的地理遗传梯度变异性,不同群体之间存在明显差异。Abstract: Objective:To analyze the spatially genetic structure of FGA and D5S818 loci of Autosome in 87 Chinese and provide the molecular biology basis for exploring Chinese origin，migration，archaeology and ethnic diversity． Methods:Aggregative indicators were obtained from gene frequency matrix and spatially genetic structure of two short tandem repeat(STR) loci were investigated under visualization by principle component analysis and spatial data analysis of geographical information system． Results:The spatially genetic structure of FGA and D5S818 loci in Chinese could be divided into four large areas，which showed increasing trend from southeastern to northwestern and southwestern area． Conclusions:The spatially genetic structures of two STR loci have evidently genetic variability gradient in different region and crowd．
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