Abstract: Objective:To explore the incidence and relative factors of post-stroke depression(PSD) at acute stage of cerebral stroke,so as to provide a basis for intervening PSD.Methods:One hundred and twenty-five cases with cerebral stroke were investigated by a self-designed questionnaire,divided into PSD group(41 cases) and non-PSD group(84 cases) according to the score of 17-item Hamilton depression rating scales,and evaluated using neurologic deficit scale and activities of daily living scale.Results:The incidence of PSD was 32.80%.Sex,age,economical status,location of damages,number of lesions,neurologic deficits and activities of daily living of patients were related with PSD,and its differences were statistical significance(P0.05-P0.01).But there were no significant differences in levels of education,marital status and nature of stroke(P0.05).Conclusions:The incidence of PSD of patients with cerebal stroke at acute stage is high,most PSD patients are mild and moderate and influenced by many factors.