血清Sestrin–2与高血压合并急性冠状动脉综合征血管病变程度相关性研究

赵胜; 刘定红; 高彦琳; 朱梦宇; 戎李; 成威

血清Sestrin–2与高血压合并急性冠状动脉综合征血管病变程度相关性研究

Study on the correlation between the serum Sestrin-2 and degree of vascular lesions in hypertension complicated with acute coronary syndrome

摘要

摘要:
目的： 探讨血清Sestrin–2在高血压合并急性冠状动脉综合征（ACS）血清中的表达及与血管病变情况的相关性。
方法： 选取高血压合并ACS病人131例为观察组，根据具体诊断细分为高血压合并不稳定型心绞痛组（UAP组）和高血压合并急性心肌梗死组（AMI组），另选68例单纯高血压病人为CON组。酶联免疫吸附测定（ELISA）检测病人血清Sestrin–2水平并分析不同分组间表达差异，应用ROC及logistic二元回归分析对Sestrin–2在高血压合并ACS中的诊断价值进行评估。
结果： AMI组中LDL、ALT和AST水平高于UAP组和CON组，AMI组Gensini高于UAP组，UAP组和AMI组中Sestrin–2水平高于CON组，差异均有统计学意义（P ＜ 0.05 ~ P ＜ 0.01）。单支病变组、双支病变组和多支病变组血清Sestrin–2水平差异无统计学意义（P ＞ 0.05）。ACS重度病变组血清Sestrin–2水平明显高于轻度及中度病变组（P ＜ 0.01）。高表达Sestrin–2和AST是高血压发生ACS的危险因素，ALT水平与ACS发生呈负相关（P ＜ 0.05）；Sestrin–2对高血压发生ACS诊断的AUC为0.614，灵敏度和特异度分别为90.8%、67.2%，95%CI：0.528～0.699。
结论： 高血压合并ACS病人中，血清Sestrin–2与冠状动脉病变密切相关，具有一定的诊断价值。

Abstract:
Objective To investigate the expression of serum Sestrin-2 in the patients with hypertension complicated with acute coronary syndrome (ACS), and its correlation with vascular lesions.
Methods A total of 131 patients with hypertension complicated with ACS were selected as the observation group. According to the specific diagnoses, the patients were divided into the hypertension complicated with unstable angina pectoris group (UAP group) and hypertension complicated with acute myocardial infarction group (AMI group). Another 68 patients with simple hypertension were selected as the CON group. The serum Sestrin-2 levels of patients were detected by enzyme-linked immunosorbent assay (ELISA), and the expression differences among different groups were analyzed. ROC and logistic binary regression analysis were used to evaluate the diagnostic value of Sestrin-2 in hypertension complicated with ACS.
Results The levels of LDL, ALT and AST in the AMI group were higher than those in UAP group and CON group, the Gensini in the AMI group was higher than that in UAP group, the levels of Sestrin-2 in the UAP group and AMI group were higher than that in CON group, and the differences were statistically significant (P ＜ 0.05 to P ＜ 0.01). There was no statistically significant difference in the serum Sestrin-2 levels among the single-vessel lesion group, double-vessel lesion group and multi-vessel lesion group (P ＞ 0.05). The serum Sestrin-2 level in the severe ACS lesion group was significantly higher than that in mild and moderate lesion groups (P ＜ 0.01). The high expression of Sestrin-2 and AST were the risk factors for ACS in hypertension, and the ALT level was negatively correlated with the occurrence of ACS (P ＜ 0.05). The AUC of Sestrin-2 for the diagnosis of ACS in hypertension was 0.614, with sensitivity and specificity of 90.8% and 67.2%, respectively, and 95%CI: 0.528–0.699.
Conclusions Among patients with hypertension complicated with ACS, the serum Sestrin-2 is closely related to coronary artery lesions, and has certain diagnostic value.

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