Abstract: Objective: To analyze the factors affecting the quality of life (QOL) of adults with epilepsy,and to explore the nursing strategies.Methods: Eighty-four patients with epilepsy were evaluated by general condition questionnaire,quality of life (QOL) in epilepsy inventory-31,social support scale,coping style questionnaire and general self-efficacy scale,and sixty healthy persons acted as control.Results: The QOL of the epilepsy group was significantly poor as compared with that of the normal control (P<0.05).The scores in general self-efficacy,coping style and social support were significantly different between the epilepsy group and the normal control group (P<0.05).The QOL score had no correlation with the gender,marriage,academic level,occupation or the type of seizure;the QOL score was negatively associated with the seizure frequency,duration of epilepsy,degree of delusion,self-reproach and retreat (P<0.05),while it was positively associated with the economic status,social support,self-efficacy,ability of solving problems and seeking help (P<0.05).Multiple regression analysis showed that the factors affecting the quality of life of the epilepsy patients were self-reproach,delusion,self-efficacy,economic status and seizure frequency in the recent 3 months.Conclusions: The life quality of the adults with epilepsy is affected by biological,psychological and social factors,and multiple interferences may help to enhance their QOL.