Abstract: Objective: To evaluate the effects and adverse reactions of the tegafur combined with body gamma knife in the treatment of patients with esophageal neoplasm complicated with retroperitoneal lymph node metastasis.Methods: The clinical data of 69 esophageal neoplasm patients with retroperitoneal lymph node metastases were retrospectively analyzed.Fixing vacuum pad and three-dimensional stereotactic body,enhancing CT scan,enlarging the tumor target area for 10 mm as planning target area,50% dose line embracing 95% planning target area as prescription dose curve and 350 to 450 cGy one time(5 times a week) were implemented at the time of body gamma knife therapy.The treatment was consist of 10 to 12 times,and the total dose of the tumor margin was 4 200-4 950 cGy.Among 69 cases,36 patients(combination group) were treated with the body gamma knife combined with tegafur(40 mg/m²,2 times 1 d,28 days 1 cycle for 4 cycles),33 patients(control group) were only treated with the body gamma knife therapy.Results: The short-term effective rate and 1-year survival rate in the combination group and control group were 86.11% & 77.78% and 63.63% & 54.54%,respectively.The 1-year survival rate in the combination group was higher than that in the control group(P<0.05).The total effective rate of pain relief in the combination group and control group were 91.18% and 77.42%,respectively,the difference of which was not statistically significant(P>0.05).The difference of the acute adverse reaction between two groups was not statistically significant(P>0.05).The patients could tolerate,and were improved after positive treatment.No case died.Conclusions: The treatment of patients with esophageal neoplasm complicated with retroperitoneal lymph node metastasis with tegafur combined with body gamma knife treatment can improve 1-year survival rate,and does not increase the adverse reaction of patients.