哌拉西林诱导铜绿假单胞菌L型形成的实验研究

Induction of Pseudomonas aeruginosa L-forms with piperacillin

摘要: 目的:观察哌拉西林诱导铜绿假单胞菌变异为L型的情况。方法:采用平板纸片法和液体浓度梯度法,利用哌拉西林药物纸片诱导铜绿假单胞菌标准菌株变异为L型,并稳定传代。结果:铜绿假单胞菌可被哌拉西林诱导为典型L型,在诱导因素存在下可稳定传代。结论:哌拉西林可诱导铜绿假单胞菌变异为稳定L型。

Abstract: Objective:To observe the induction of Pseudomonas aeruginosa(P.aeruginosa) L-forms with piperacillin.Methods:In plate and liquid media within antibiotic piperacillin,P.aeruginosa was induced into L-forms which would go down to posterity stably.Results:P.aeruginosa was induced to typical and stable L-forms by piperacillin.Conclusions:P.aeruginosa L-form is an important existing form of P.aeruginosa.