Objective To investigate the correlations between the high-sensitivity C-reactive protein (hs-CRP) and levels of inflammatory factor in patients with gallstones (GSD).

Methods Two hundred and fifty-six patients with GSD were collected as research objects, 161 patients with simple gallstones were divided into the simple GSD group, and 95 patients with GSD complicated with cholangitis were divided into the cholangitis group. A total of 256 healthy subjects were set as control group at the same time. The levels of tumor necrosis factor-alpha, interleukin-6, IL-19, IL-10, hs-CRP and liver function indexes were determined, and the influencing factors of cholangitis in GSD patients were analyzed.

Results The levels of hs-CRP, TNF-Alpha, IL-6 and IL-19 in the GSD group were significantly higher than those in control group, while the levels of IL-10 were significantly lower than those in control group (P ＜ 0.01). The levels of hs-CRP, TNF-α, IL-6 and IL-19 in the cholangitis group were significantly higher than those in GSD group, and the levels of IL-10 were significantly lower than those in GSD group (P ＜ 0.01). The hs-CRP was positively correlated with the levels of TNF-Alpha, IL-6 and IL-19 (r = 0.472, P ＜ 0.01). The results of multivariate logistic regression analysis showed that the hs-CRP, TNF-Alpha, IL-6, IL-19 and IL-10 were the independent influencing factors of GSD patients complicated with cholangitis (P ＜ 0.05 ~ P ＜ 0.01).

Conclusions The serum levels of hs-CRP, TNF-Alpha, IL-6 and IL-19 significantly increase, the IL-10 level significantly decrease in GSD patients, and both are the independent influencing factors of GSD patients complicated with cholangitis.