Abstract: Objective: To observe the effects of preemptive analgesia of parecoxib sodium on preventing agitation in recovery period of general anaesthesia.Methods: Sixty patients with ASA Ⅰ-Ⅱ scheduled with operation were randomly divided into the parecoxib sodium group(P group) and control group(C group)(30 cases each group).Ten minutes before general anesthesinduction,the group P and group C were injected with 40 mg of parecoxib sodium(4 ml) and 4 ml of normal saline,respectively.The time of spontaneous breathing recovery and extubation,the incidence and degree of agitation in anesthesia recovery period,the pain score at 10 minutes after extubation of all patients were observed.The incidence of adverse reactions,such as nausea and vomiting in recovery period,drowsiness and respiratory depression,of all patients were recorded.Results: There were not statistically significant in the time of spontaneous breathing recovery and extubation between two groups(P>0.05).Compared with group C,the incidence and degree of agitation and pain score at 10 minutes after extubation in group P were significantly lower(P<0.01).One case with nausea in group C in recovery period was found,no vomiting,drowsiness and respiratory depression were found in two groups.Conclusions: The injection with 40 mg of parecoxib sodium 10 minutes before general anesthesia induction can play analgesic effect,reduce and prevent the agitation in anesthesia recovery period and significantly improve the safety of the recovery period,but it doesn't prolong the time of spontaneous breathing recovery and extubation.