Abstract: Objective: To explore the surgical therapy of lower extremity arteriosclerosis disease.Methods: The traditional artery bypass or extra-anatomic bypass graft surgery wer adopted in 37 patients,the interventional therapy was adopted in 27 cases,and the traditional surgery and interventional surgery in 18 cases.Results: Seventy-one cases achieved good results,which symptoms significantly improved.Ankle brachial index (ABI) was significantly increased.Postoperative CT angiography showed a marked increase in distal arterial patency rate.Six cases graft showed vascular thrombosis.Three cases with no good results were amputated.Two cases were dead with complication.Conclusions: There are various surgical therapies for lower extremity arteriosclerosis disease.The most suitable therapy has to be on comprehensive consideration of the patient general condition,lesion locations,ranges etc.