陈凯, 于在诚. 血清胸苷激酶1检测在食管癌诊治中的应用[J]. 蚌埠医科大学学报, 2013, 37(4): 424-426.
    引用本文: 陈凯, 于在诚. 血清胸苷激酶1检测在食管癌诊治中的应用[J]. 蚌埠医科大学学报, 2013, 37(4): 424-426.
    CHEN Kai, YU Zai-cheng. The clinical value of serum thymidine kinase test in the diagnosis and treatment of esophageal cancer[J]. Journal of Bengbu Medical University, 2013, 37(4): 424-426.
    Citation: CHEN Kai, YU Zai-cheng. The clinical value of serum thymidine kinase test in the diagnosis and treatment of esophageal cancer[J]. Journal of Bengbu Medical University, 2013, 37(4): 424-426.

    血清胸苷激酶1检测在食管癌诊治中的应用

    The clinical value of serum thymidine kinase test in the diagnosis and treatment of esophageal cancer

    • 摘要: 目的:探讨血清细胞质胸苷激酶1(TK1)检测在食管癌诊治中的应用价值。方法:利用增强化学发光法检测158例确诊为食管癌患者(食管癌组)术前血清TK1的水平,同时检测40例食管良性疾病(良性疾病组)和50名健康人(对照组)血清中的TK1水平;食管癌组随机抽取28例进行连续跟踪随访,检测其术后7 d、术后1个月的血清TK1水平。结果:食管癌组患者术前血清TK1水平和血清TK1阳性率均高于良性疾病组和对照组(P0.01),良性疾病组与对照组差异无统计学意义(P0.05);食管癌组中随访的28例患者手术后7 d血清TK1下降不明显(P0.05),但术后1个月较术前明显下降(P0.01)。结论:检测血清TK1的水平对食管癌诊断、预后判断、疗效监测等方面有一定的价值。

       

      Abstract: Objective:To investigate the clinical application value of serum thymidine kinase 1(TK1) test in the diagnosis and treatment of esophageal cancer.Methods:The TK1 level of 158 cases with esophageal cancer before operation(esophageal cancer group),40 cases with benign esophageal disease(benign disease group) and 50 healthy people(control group) were measured by enhanced chemiluminescence.In the esophageal cancer group,28 patients were randomly selected for following-up,their TK1 level were measured at 7 days and 1 month after operation.Results:The TK1 level before the operation and its positive rate in the esophageal cancer group were higher than those in the benign disease group and control group(P0.01),but the difference between the benign disease group and control group was not statistically significant(P0.05).Compared with preoperation,the TK1 levels of the 28 patients followed-up did not obviously decreased at 7 days(P0.05),but it decresed obviously in 1 month after operation in the esophageal cancer group(P0.01).Conclusions:The TK 1 test has certain clinical application value in the diagnosis,prognosis and curative effects of esophageal cancer.

       

    /

    返回文章
    返回