孔亮, 王引明, 桂树华. 甘露醇对脑出血患者脑血流状况的影响[J]. 蚌埠医学院学报, 2012, 36(6): 679-680.
    引用本文: 孔亮, 王引明, 桂树华. 甘露醇对脑出血患者脑血流状况的影响[J]. 蚌埠医学院学报, 2012, 36(6): 679-680.
    KONG Liang, WANG Yin-ming, GUI Shu-hua. The effects of mannitol on cerebral blood flow condition of patient with cerebral hemorrhage[J]. Journal of Bengbu Medical College, 2012, 36(6): 679-680.
    Citation: KONG Liang, WANG Yin-ming, GUI Shu-hua. The effects of mannitol on cerebral blood flow condition of patient with cerebral hemorrhage[J]. Journal of Bengbu Medical College, 2012, 36(6): 679-680.

    甘露醇对脑出血患者脑血流状况的影响

    The effects of mannitol on cerebral blood flow condition of patient with cerebral hemorrhage

    • 摘要: 目的:探讨甘露醇对脑出血患者脑血流状况的影响。方法:对42例原发性脑出血患者经颅多普勒动态监测,记录甘露醇治疗前后双侧大脑中动脉(middle cerebral arteries,MCA)平均血流流速(mean flow velocities,MFV)及搏动指数(pulsatilityindex,PI)。结果:甘露醇治疗前后病灶侧MPV和PI差异均无统计学意义(P0.05);而健侧MPV均低于病灶侧(P0.01),并且注射后10、60 min均低于治疗前,健侧PI均高于病灶侧(P0.05~P0.01),而注射后10、60 min PI均高于治疗前(P0.01),注射后60 min亦高于注射后10 min(P0.01)。结论:脑出血患者应用甘露醇可增加病灶侧脑MFV和健侧动脉PI,从而改善病灶周围脑组织的灌注。

       

      Abstract: Objective:To explore the effects of mannitol on cerebral blood flow condition of patient with cerebral hemorrhage.Methods:Forty-two patients with cerebral hemorrhage were detected by transcranial Doppler and the mean flow velocities(MFV) and pulsatility index(PI) of bilateral middle cerebral arteries(MCA) were recorded before and after treatment with mannitol.Results:The MFV and PI of the affected side had no significant difference before and after treatment with mannitol(P0.05),the MPV of the normal side were lower than that of the affected side(P0.01),the data at 10 and 60 min after injecting mannitol were lower than that of before treatment.The PI of the normal side were higher than that of the affected side(P0.05 to P0.01),and the data at 10 and 60 min after injecting mannitol were higher than that of before treatment and which were higher at 10 min than that of at 60 min(P0.01).Conclusions:Mannitol can increase the MFV of the affected side and the PI of the normal side of patient with cerebral hemorrhage,and improve the blood perfusion around the affected brain tissue.

       

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