Effect of sevoflurane preconditioning on hemodynamics and QT dispersion following carbon dioxide pneumoperitoneum in hypertension patients
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摘要: 目的:探讨七氟烷预处理对高血压患者二氧化碳(CO2)气腹后QT离散度(QTd)与血流动力学的影响。方法:60例腹腔镜胆囊切除术高血压患者随机均分为七氟烷预处理组(预处理组)和对照组。预处理组于气腹前吸入1个最低肺泡有效浓度七氟烷15 min,随后快速充氧进行气体交换10 min;对照组常规全身静脉麻醉维持。记录麻醉诱导前(T0)、气腹前(T1)、气腹后即刻(T2)和气腹后5 min(T3)、气腹后10 min(T4)的QTd值以及平均动脉压(MAP)、心率(HR)的变化。结果:预处理组T2、T3和T4时间点的MAP和HR及T2和T3 QTd均低于对照组(P0.05～P0.01)。结论:七氟烷预处理能缩短高血压患者CO2气腹后QTd,稳定CO2气腹后的血流动力学变化。Abstract: Objective:To investigate the effect of sevoflurane preconditioning on QT dispersion(QTd) and hemodynamical changes following carbon dioxide(CO2) pneumoperitoneum in hypertension patients.Methods:Sixty hypertension patients who received laparoscopic cholecystectomy were divided into sevoflurane pretreatment group(30 cases) and control group(30 cases) randomly.The QTd values,mean arterial pressure(MAP) and heart rate(HR) were recorded in pre-induction(T0),before pneumoperitoneum(T1),and immediately(T2),at 5 min(T3),at 10 min(T4) after pneumoperitoneum.Results:In pretreatment group,MAP,HR and QTd value at T2,T3 and T4 were lower than those in control group(P0.05 to P0.01).Conclusions:Sevoflurane preconditioning can shorten QTd value and stabilize hemodynamical changes after CO2 pneumoperitoneum in hypertension patients.
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Keywords:
- hypertension /
- sevoflurane /
- QT dispersion /
- hemodynamics /
- pneumoperitoneum
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