Abstract: Objective:To investigate the correlation of serum markers and liver fibrosis pathological stage in patients with chronic hepatitis B.Methods:The routine pathological examination of liver biopsy was tested in 214 cases of hepatitis B patients,the serum markers of liver fibrosis and liver function parameters,blood coagulation index and HBV-DNA level were also measured.The correlation of the test items and liver fibrosis stage was discussed.Results:There were statistical differences about hyaluronic acid,laminin,Ⅳ collagen,Ⅲ procollagen and other 10 test items with pathological stages of liver fibrosis(P0.01).Conclusions:Hyaluronic acid,laminin,collagen Ⅳ,collagen Ⅲ and other serum test could be effective in diagnosis of hepatitis B patients with liver fibrosis,and they can predict the trend of liver fibrosis.