金进. 泼尼松联合甲巯咪唑与单纯口服甲巯咪唑治疗Graves病疗效比较[J]. 蚌埠医学院学报, 2012, 36(6): 699-701.
    引用本文: 金进. 泼尼松联合甲巯咪唑与单纯口服甲巯咪唑治疗Graves病疗效比较[J]. 蚌埠医学院学报, 2012, 36(6): 699-701.
    JIN Jin. Comparison of efficacy prednisone combined with oral methiamazole with simple oral methiamazole of treating Graves' disease[J]. Journal of Bengbu Medical College, 2012, 36(6): 699-701.
    Citation: JIN Jin. Comparison of efficacy prednisone combined with oral methiamazole with simple oral methiamazole of treating Graves' disease[J]. Journal of Bengbu Medical College, 2012, 36(6): 699-701.

    泼尼松联合甲巯咪唑与单纯口服甲巯咪唑治疗Graves病疗效比较

    Comparison of efficacy prednisone combined with oral methiamazole with simple oral methiamazole of treating Graves' disease

    • 摘要: 目的:比较泼尼松联合甲巯咪唑与单纯口服甲巯咪唑治疗Graves病的疗效。方法:收集74例Graves病患者,随机分为观察组与对照组,每组37例,观察组应用泼尼松联合甲巯咪唑口服,而对照组单纯口服甲巯咪唑治疗,观察随访1年,比较2组患者临床疗效、甲状腺素水平变化、相关免疫指标变化、不良反应及并发症发生情况。结果:观察组有效率91.89%,明显优于对照组70.27%(P0.05);治疗后2组患者FT3、FT4水平较治疗前下降,促甲状腺激素较治疗前升高,IgG、IgM水平降低,且观察组较对照组明显(P0.01);而观察组不良反应及并发症发生率13.51%及10.81%,低于对照组的37.84%及32.43%(P0.05)。结论:泼尼松联合口服甲巯咪唑治疗Graves病明显优于单纯口服甲巯咪唑,显著改善甲状腺激素水平及免疫指标,减少不良反应及并发症的发生,值得推广应用。

       

      Abstract: Objective:To investigate the clinical efficacy of prednisone combined with oral anti-thyroid drugs and simple oral anti-thyroid drugs for treating Graves' disease.Methods:Seventy-four cases with Graves' disease were randomly divided into observation group,which were treated with prednisone and methimazole of oral anti-thyroid and control group,which were treated with methimazole(37 cases in each group).All cases were followed up for 1 year,and the clinical efficacy,thyroid hormone levels,related immune indicators,toxicity and complications of two groups were analysed.Results:The 91.89% of clinical efficacy of the observation group was significantly higher than 70.27% of the control group(P0.05).Compared with the pre-treatment,the decreasing FT3,FT4,IgG and IgM levels and the increasing thyroid stimulating hormone levels were observed after treatment,and there were significant differences between the two groups(P0.01).There were 13.51% of side effects and 10.81% of complications of the observation group were significantly lower than 37.84% and 32.43% of the control group respectively(P0.05).Conclusions:The efficacy of prednisone combined with oral anti-thyroid drugs for treating Graves' disease is better than that of oral anti-thyroid drugs only,which can significantly improve the clinical efficacy,thyroid hormone levels,immune parameters and reduce toxicity,so as to be worth spreading.

       

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