郭政新, 王兆华, 刘欣, 李娜, 常先友. 蚌埠地区结核杆菌耐药情况分析与对策[J]. 蚌埠医学院学报, 2013, 37(4): 469-470.
    引用本文: 郭政新, 王兆华, 刘欣, 李娜, 常先友. 蚌埠地区结核杆菌耐药情况分析与对策[J]. 蚌埠医学院学报, 2013, 37(4): 469-470.
    GUO Zheng-xin, WANG Zhao-hua, LIU Xin, LI Na, CHANG Xian-you. The preliminary analysis and countermeasures of the drug resistance of Mycobacterium tuberculosis in Bengbu[J]. Journal of Bengbu Medical College, 2013, 37(4): 469-470.
    Citation: GUO Zheng-xin, WANG Zhao-hua, LIU Xin, LI Na, CHANG Xian-you. The preliminary analysis and countermeasures of the drug resistance of Mycobacterium tuberculosis in Bengbu[J]. Journal of Bengbu Medical College, 2013, 37(4): 469-470.

    蚌埠地区结核杆菌耐药情况分析与对策

    The preliminary analysis and countermeasures of the drug resistance of Mycobacterium tuberculosis in Bengbu

    • 摘要: 目的:了解蚌埠地区肺结核患者的结核杆菌耐药情况,为进一步开展耐药结核患者的诊治提供依据。方法:采用萋-尼抗酸染色法筛查出425例耐药肺结核高危患者,痰涂片检查阳性者采用酸性改良罗氏固体培养基进行分枝杆菌培养,培养阳性者采用绝对浓度间接法进行药敏试验。结果:痰培养阳性患者267例,耐药肺结核患者184例。其中单耐药45例,多耐药76例,耐多药41例,严重耐多药22例。结论:蚌埠地区肺结核患者耐药情况严重,预防耐药肺结核发生,关键是制定合理有效的治疗方案,加强全程督导管理。

       

      Abstract: Objective:To study the drug resistance of Mycobacterium tuberculosis(TB) in Bengbu for providing the basis of the diagnosis and treatment of patients with drug-resistant TB.Methods:Four hundred twenty-five high risk patients were screened by Ziehl-Neelsen anti-acid staining.The mycobacterium tuberculosis of sputum in the positive patients were cultured with acid modified Roche solid culture medium,and the drug sensitive test of the cultured positive patients were measured by the indirect method of absolute concentration.Results:Patients with positive sputum culture were 267 cases.Patients with drug-resistant TB were 184 cases,including 45 cases of single-drug resistance,76 cases of multidrug resistance,41 cases of multiple drug resistance and 22 cases of extensively drug resistance.Conclusions:The drug resistance of patients with TB is serious in Bengbu.The specialist out-patient treatment,making reasonable and effective treatment and strengthening the supervision management is a key to prevent the drug resistance of patient with TB.

       

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