Abstract: Objective:To observe the changes of serum uric acid(SUA)in patients with the chronic kidney disease(CKD)at different stages and to explore the influence of SUA and C-reactive protein(CRP)on the cardiovascular diseases in them.Methods:One hundred and ninety-four hospitalized CKD patients were examined of the level of SUA,CRP and brain natriuretic peptide(BNP).The changes of SUA at different stages of CKD were compared,and the correlation of SUA with CRP,SUA and CRP with BNP were evaluated.Results:The incidence of hyperuricemia increased in accordance with the CKD stage(P0.01).The level of SUA was negatively correlated with the GFR(P0.05),but the level of SUA in patients with CKD of stage 1,stage 2,stage 4 and stage 5 had no significant difference(P0.05).The level of CRP in CKD patients complicated with hyperuricemia was higher than that with normal uric acid group.The SUA and CRP were positively correlated with BNP(P0.05).The BNP in CKD patients complicated with hyperuricemia,hyperuricemia and elevated CRP groups was significantly higher than that in SUA and normal uric acid group(P0.01).Conclusions:The level of serum SUA and hyperuricemia increase with the progress of CKD.The level of SUA may relate to that of CRP and hyperuricemia is highly associated with cardiovascular diseases,which could increase the incidence of cardiovascular complications in CKD patients.