PTEN在眼睑结膜鳞状细胞癌中的表达及其临床意义
Expression and clinical significance of PTEN in squamous cell carcinoma of the eyelid conjunctiva
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摘要: 目的:探讨抑癌基因PTEN在眼睑结膜鳞状细胞癌中的表达缺失及与其发生、发展的关系。方法:采用免疫组化EliVision法染色,对34例眼睑结膜鳞状细胞癌和10例癌旁正常组织标本进行PTEN标记,观察并分析表达情况。结果:眼睑结膜鳞状细胞癌中PTEN蛋白阳性率23.53%,癌旁正常眼睑组织中PTEN蛋白阳性率100.00%,眼睑结膜鳞状细胞癌组织的表达明显低于癌旁组织(P0.01);在中高分化的眼睑结膜鳞状细胞癌中PTEN阳性率34.78%,在低分化癌中其阳性率0.00%,差异有统计学意义(P=0.034)。结论:眼睑结膜鳞状细胞癌中PTEN蛋白的不表达或表达下降可能与眼睑结膜鳞状细胞癌的发生、发展有一定关系。Abstract: Objective:To investigate the expression lack and effects of PTEN in squamous cell carcinoma of the eyelid conjunctiva(SCC).Methods:The expression of PTEN of 34 patients with squamous cell carcinoma of the eyelid conjunctiva and adjacent tissue of 10 patients were detected and statistically analysed through EliVision immunohistochemical method.Results:The positive expression rate of PTEN protein was 23.53% in squamous cell carcinoma of the eyelid conjunctiva,which were significantly less than that of adjacent tissue(100.00%)(P0.01).The 34.78% and 0.00% expression of PTEN in a well-differentiated and poorly differentiated SCC were detected,and the difference had statistically significant(P=0.034).Conclusions:The expression lack and low expression of squamous cell carcinoma of the eyelid conjunctiva may have a certain relation with the occurrence and development of tumor.
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