黄丽丽, 许礼发. 细胞因子基因型多态性与HPV引起的子宫颈损伤相关性研究[J]. 蚌埠医学院学报, 2012, 36(7): 783-784,787.
    引用本文: 黄丽丽, 许礼发. 细胞因子基因型多态性与HPV引起的子宫颈损伤相关性研究[J]. 蚌埠医学院学报, 2012, 36(7): 783-784,787.
    HUANG Li-li, XU Li-fa. Research of gene polymorphism of cytokines on human papilloma virus induced cervical injury[J]. Journal of Bengbu Medical College, 2012, 36(7): 783-784,787.
    Citation: HUANG Li-li, XU Li-fa. Research of gene polymorphism of cytokines on human papilloma virus induced cervical injury[J]. Journal of Bengbu Medical College, 2012, 36(7): 783-784,787.

    细胞因子基因型多态性与HPV引起的子宫颈损伤相关性研究

    Research of gene polymorphism of cytokines on human papilloma virus induced cervical injury

    • 摘要: 目的:探讨肿瘤坏死因子(TNF-)、转化生长因子1(TGF-1)、白细胞介素10(IL-10)、IL-18和干扰素-(IFN-)基因型多态性与人乳头瘤病毒(HPV)阳性的子宫颈损伤相关性。方法:选择本院就诊的42例子宫颈癌患者,另选择87名HPV阴性、阴道镜检查正常的妇女作为对照,检测两组TNF-、TGF-、IL-10、IL-18和IFN-的基因型多态性。结果:TNF-、IL-10、IL-18和TGF-表型的表达在HPV阳性与HPV阴性妇女中差异均无统计学意义(P0.05)。但IFN-在中度和高表达者比率HPV阳性患者明显增加(P0.01)。结论:利用细胞因子基因多态性可能有利于为HPV子宫颈癌前病变的影响进一步提供相关信息。

       

      Abstract: Objective:To explore the polymorphism of tumor necrosis factor-(TNF-),transforming growth factor beta1(TGF-1),interleukin 10(IL-10),IL-18,and interferon-(IFN-) genes with human papilloma virus(HPV) positive cervical injury.Methods:A case-control study was conducted on 42 women presenting with HPV infection and cervical lesion and 87 HPV-negative women,and the single nucleotide polymorphisms of TNF-,TGF--,IL-10,IL-18 and IFN-genes were observed and compared.Results:There was nosignicant difference on the cytokine polymorphisms including TNF-,IL-10,IL-18 and TGF- between HPV positive and HPV negative women(P0.05),while the proporaficn of medium and high expression of IFN- was increased significantly in HPV positive women(P0.01).Conclusions:Cytokine polymorphisms measurement may be useful for providing further information regarding their influence in HPV-related cervical lesion.

       

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