刘健, 李胜泽, 崔艳艳. 子宫颈微偏离腺癌2例报道并文献复习[J]. 蚌埠医学院学报, 2009, 34(7): 573-576.
    引用本文: 刘健, 李胜泽, 崔艳艳. 子宫颈微偏离腺癌2例报道并文献复习[J]. 蚌埠医学院学报, 2009, 34(7): 573-576.
    LIU Jian, LI Sheng-ze, CUI Yan-yan. Minimal deviation adenocarcinoma of cervix: report of 2 cases and review of the literature[J]. Journal of Bengbu Medical College, 2009, 34(7): 573-576.
    Citation: LIU Jian, LI Sheng-ze, CUI Yan-yan. Minimal deviation adenocarcinoma of cervix: report of 2 cases and review of the literature[J]. Journal of Bengbu Medical College, 2009, 34(7): 573-576.

    子宫颈微偏离腺癌2例报道并文献复习

    Minimal deviation adenocarcinoma of cervix: report of 2 cases and review of the literature

    • 摘要: 目的:探讨子宫颈微偏离腺癌(minimal deviation adenocarcinoma,MDA)的临床特征、组织病理学形态、诊断、鉴别诊断及治疗方法。方法:复习2例MDA的相关临床资料,并对其进行组织学观察,结合文献进行探讨。结果:MDA患者白带增多呈水样。颈管粗大外观正常,无特异性,子宫颈活检易漏诊。子宫颈肥大呈桶状,切面见子宫颈纤维肌层增厚,质地硬,有多个不规则微小囊腔形成。大部分肿瘤细胞异型性小,接近正常子宫颈黏液性腺上皮,但腺体大多呈不规则的囊状扩张、扭曲,有鸡爪样触角形成,腺体呈浸润性生长,并有纤维间质反应,肿瘤组织易侵犯脉管和神经组织。2例预后均很差。结论:MDA是一种较罕见的、细胞学异型性极轻微、宫颈刮片及活检不易明确诊断的、易被诊断为潜在恶性而生物学行为为恶性的子宫颈腺瘤。

       

      Abstract: Objective: To study the clinical and histo pathological features,diagnosis,differential diagnosis and treatment of minimal deviation adenocarcinoma(MDA) of cervix.Methods: The clinical data of two cases of MDA were collected.Histopathological examination was performed and the literature related was reviewed.Results: The main clinical symptoms of MDA were watery leucorrhea,and large and hard cervix.It was often misdiagnosed by biopsy.There were many irregular microcysts in the cervix wall,and the cervix wall was hypertrophic.The pathological findings showed hyperplasia of the glands,which were irregular,twisted and cystic,feeling like chicken claw.Invasion was often observed around the vessels and the nervous tissues.The prognosis of the two cases was very poor.Conclusions: MDA is a kind of malignant adenoma of cervix with little dysplasia in cytology.MDA is very difficult to diagnose with cytological examination and biopsy,and is often misdiagnosed as benign tumor,but has a malignant biological behavior.

       

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