Abstract: Objective: To observe the clinical effect of intravenous pantoprazole、omeprazole for the management of peptic ulcer bleeding.Methods: Sixty-five patients with peptic ulcer bleeding were randomly divided into pantoprazole group(35 cases) and omeprazole group(30 cases).Which were administered intravenously pantoprazole(80 mg) and omeprazole(40 mg) twice daily respectively.To observe the clinical effective and adverse reaction.Results: There were no significant differences between The total effective rates of pantoprazole group and omeprazole group 94.3% vs 96.7%(P>0.05).But there were significant differences between the adverse reactions of pantoprazole group and omeprazole group 5.72% vs 26.67%(P<0.05).Conclusions: Intravenous pantoprazole is effective in the management of peptic ulcer bleeding and there's little adverse reaction.It is worthy further application in clinic.