Abstract: Objective:To observe the efficacy and safety of sodium ozagrel combined with low molecular weight heparin calcium on patients with progressive cerebral infarction.Methods:Fifty-two cases with acute progressive cerebral infarction were randomly divided into treatment and control groups(26 cases in each group).The patients in control group were only intravenously infused with 80mg of sodium ozagrel two times every day for 14 days on the basis of regular treatment,and the patients in treatment group were subcutaneous injected with low-molecular heparin calcium 5 000 U on the basis of control group,once a day for one week.The therapeutic effect was evaluated by National Institutes of Health Stroke Scale(NIHSS) and Bathal index(BI).Platelet count,coagulation time were detected before and after 7th and 14th day.Results:NIHSS was improved after treatment for one week,and BI scores were markedly improved after treatment one or two weeks in treatment group,which were significantly higher than those in control group(P0.01).Platelet count,coagulation time were within normal range,there was no obvious side effect in either group.Conclusions:Sodium ozagrel combined with low molecular weight heparin calcium was an effective and safe therapy for treatment with progressive cerebral infarction.