Abstract: Objective:To compare the efficacy of azasetron in combination with dexamethasone and single drug alone in reduction of postoperative nausea and vomiting(PONV) after gynecological surgery.Methods:Eighty-nine patients were received epidural anesthesia for gynecological surgery.They were randomly divided into three groups after operation:group AD,azasetron at 10 mg combination with dexamethasone at 10 mg intravenously;group A,azasetron at 10 mg alone intravenously,and group NS with 0.9% NaCl 5 ml intravenously.The incidence rate of PONV was recorded after operation and HR,MAP,SpO2were measured before and after treatment in each group.Results:The results showed that the incidence of PONV in group AD was significantly lower than that in group NS(P0.01).There was no difference on HR,MAP,SpO2in each group(P0.05).Conclusions:This study indicates that azasetron combined with dexamethasone can prevent and reduce postoperative nausea and vomiting following gynecological procedure.