双波长紫外分光光度法测定家兔隔室模型血清茶碱浓度及其药动学参数

Determination serum theophylline concentration through two wavelength ultraviolate spectrophotometry and working out its pharmacokinetic parameters

摘要: 目的:判断静脉注射(静注)氨茶碱在家兔体内的隔室模型,计算相关药代动力学参数。方法:双波长紫外分光光度法测定家兔静注氨茶碱后的血清茶碱浓度,根据相关药代动力学理论研究其药动学。结果:静注氨茶碱在体内符合二室模型,药动学方程为C=14.46e-3.451t+10.40e-0.114t。结论:可以用双波长紫外分光光度法测定茶碱血药浓度,在体内代谢符合二室模型,并可计算出其药动学方程。

Abstract: Objective: To judge the compartment model of aminophylline by vessel injection and work out its pharmacokinetic parameters.Methods: The serum theophylline concentration by vessel injection was detected through two wavelength ultrviolet spectrophotometry,and the pharmacokenetic parameters were studied according to the related theory.Results: The compartment model of aminophylline by vessel injection matched the double compartment model,the formula of its pharmacokinetics was C = 14.46e-3.451t+10.40e-0.114t.Conclusions: The serum theophylline concentration could be detected by two wavelength ultraviolate spectrophotometry,its metabolism in body matched the double compartment model,the formula of its pharmacokinetics could also be made out.