Abstract: Objective:To explore the clinical characteristics of acute promyelocytic leukemia(APL) with CD2+.Methods:The immunophenotype of 19 cases with APL were detected by flow cytometry.All cases were divided into CD2+ and CD2-group according to the results of immunophenotype.The clinical performance,laboratory examination and therapeutic effects of two groups were analysed.Results:Compared with 15 cases with CD2-,the higher WBC counts and lower fibrinogen contents of 4 cases with CD2+ were observed(P0.05),and the differences of platelet counts and CR time of two groups had no statistical significance(P0.05).The CD34 expressions were detected in all 4 cases with CD2+,which could complete remission after treatment.The CD34 expression was detected in 1 of 15 cases with CD2-and other 14 cases could complete remission after treatment.Conclusions:APL with CD2+ are often accompanied by high WBC counts and risk of serious bleeding,which can be used as an indicator to monitor the minimal residual disease of APL.