Abstract: Objective:To explore the operation key points,safety and therapeutic effects of trabeculectomy on glaucoma with persistent intraocular hypertension.Methods:Twenty-seven patients with persistent intraocular hypertension were treated with trabeculectomy.The eyesight,intraocular pressure(IOP),the depth of anterior chamber and complications were detected after operation.Results:All operations were completed successfully.The suprachoroidal hemorrhage and malignant glaucoma were not found at the intraoperation and postoperation.Five eyes with hyphema and 10 eyes with shallow anterior chamber recovered after treatment.The eyesights of 18 eyes were improved and the IOP of 24 eyes(88.89%) were controlled less than 21 mmHg without drugs treatment.Conclusions:Surgical intervention should be performed when IOP can not be controlled by drugs,which can shorten the course of disease and obtain beneficial effects.