刘丽华, 刘超, 王静. 盆腔炎合剂对子宫平滑肌活动的作用[J]. 蚌埠医学院学报, 2013, 37(6): 658-660.
    引用本文: 刘丽华, 刘超, 王静. 盆腔炎合剂对子宫平滑肌活动的作用[J]. 蚌埠医学院学报, 2013, 37(6): 658-660.
    LIU Li-hua, LIU Chao, WANG Jing. Effect of mixture penqiangyan on uterine smooth muscle[J]. Journal of Bengbu Medical College, 2013, 37(6): 658-660.
    Citation: LIU Li-hua, LIU Chao, WANG Jing. Effect of mixture penqiangyan on uterine smooth muscle[J]. Journal of Bengbu Medical College, 2013, 37(6): 658-660.

    盆腔炎合剂对子宫平滑肌活动的作用

    Effect of mixture penqiangyan on uterine smooth muscle

    • 摘要: 目的:观察盆腔炎合剂对家兔在体和大鼠离体子宫平滑肌活动的作用。方法:家兔随机分为空白对照组、盆腔炎合剂(8.1、16.3g和32.5g/kg)组和妇炎康复合剂(4.5g/kg)组采用十二指肠给药;大鼠随机分为空白对照组、盆腔炎合剂(11.4、22.8和45.5g/kg)组和妇炎康复合剂(7.0g/kg)组,每天口服给药2次,连续3d后,采集血液分离含药血清,然后分离得到大鼠离体子宫并分别以上述含药血清处理,观察子宫平滑肌收缩情况。结果:盆腔炎合剂16.3g/kg和32.5g/kg组显著提高家兔在体子宫平滑肌收缩幅度(P0.05),且盆腔炎合剂16.3g/kg组疗效优于盆腔炎合剂8.1g/kg组(P0.05)。盆腔炎合剂91.0g/kg组含药血清可显著增加大鼠离体子宫的收缩幅度和收缩活力(P0.05~P0.01),盆腔炎合剂45.5g/kg组含药血清仅对子宫收缩的幅度有增加作用(P0.05)。结论:盆腔炎合剂能促进子宫活动,可能对慢性盆腔炎症状有一定改善作用。

       

      Abstract: Objective:To observe in vivo effect of mixture penqiangyan on rabbit uterine smooth muscle movement andin vivoeffect of mixture penqiangyan on rat uterine smooth muscle movement.Methods:rabbits were grouped into control group,mixture penqiangyan groups(8.1,16.3 and 32.5 g/kg)and mixture fuyankangfu group(4.5g/kg)with duodenal administering.rats were grouped into control group,mixture penqiangyan groups(11.4,22.8 and 45.5g/kg)and mixture fuyankangfu group(7.0 g/kg)with oral administering twice a day for three days.Three days later,mixture penqiangyan containing serum was isolated from the rats and rat uterine isolated were incubated with mixture penqiangyan containing serumin vivo.Results:Sixteen point three g/kg and 32.5 g/kg of mixture penqiangyan significantly excite amplitude of rabbit uterine contractionin vivo(P0.05),and effect of 16.3 g/kg of mixture penqiangyan is better than that of 8.1g/kg.Further study showed that 91.0 g/kg of mixture penqiangyan containing serum significantly excite amplitude and activity of rat uterine contraction in vitro(P0.05-P0.01),while 45.5 g/kg of mixture penqiangyan containing serum only increased the amplitude of rat uterine contraction(P0.05).Conclusions:Mixture penqiangyan may improve symptoms of chronic pelvic inflammatory disease by exciting uterine smooth muscle.

       

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