Abstract: Objective:To evaluate the efficiency and safety of moxifloxacin on acute exacerbation of chronic obstructive pulmonary disease(AECOPD)in elderly patients.Methods:Seventy-eight elderly patients with AECOPD were randomly divided into observation group and control group.In control group,38 patients were treated with levofloxacin at 0.4g,intravenous infusion,one time per day;The 40 patients in observation group were treated with moxifloxacin at 0.4g intravenous infusion,one time per day;the treatment lasted 7-14 days in the two group,the total effective rate、bacterial eradication rate and drug reaction were compared between the two groups.Results:In moxifloxacin group,the effective rate was 87.5%,in levofloxacin group,the effective rate was 73.7%,there had statisticaldifferences(P0.05).The bacterial eradication rate and adverse drug reaction rate were 90.5% and 7.5% in moxifloxacin group vs 58.8% and 10.5% in levofloxacin group,which had no statistical differences(P0.05).Conclusions:Moxifloxacin is an effective and safe drug in treatment of AECOPD in elderly patients.