Abstract: Objective:To investigate the expression of KAI1/CD82 in laryngeal squamous cell carcinoma(LSCC),and its correlation with clinic pathological parameters.Methods:The expression of KAI1/CD82 of 83 specimens of LSCC tissue and 20 specimens of normal laryngeal tissue were detected by immunohistochemistry.Results:The positive expression rates of KAI1/CD82 in LSCC tissue and normal laryngeal tissue were 41.0% and 90.0%,respectively,which had significant difference(P0.01).The high differentiation and no lymph node metastasis of LSCC tissues were observed.The positive expression rates of KAI1/CD82 of cases with grade Ⅰ-Ⅱ were significantly higher than that of cases with grade Ⅲ-Ⅳ and lymph node metastasis(P0.05 to P0.01),while its expression was not associated with age,gender,diameter and location of tumor(P0.05).Conclusions:The expression of KAI1/CD82 is closely related to the invasion and metastasis of LSCC,which can be an important indictor.