Abstract: Objective: To investigate the clinical efficacy of rectal mucosa columnar ligation injection combined with anal tightening operation in the treatment of rectal prolapse.Methods: Thirty patients with rectal prolapse were treated with rectal mucosa columnar ligation injection combined with anal tightening operation,the curative effects were observed.Results: Among 30 patients with rectal prolapse,29 cases cured,and 1 case improved,the cure rate of which was 96.67%(29/30).The differences of the levels of WBC,RBC,Hb and PLT in all csase before and after operation were not statistically significant(P>0.05).The neutrophils level at 1 day after operation was significantly higher than that in before operation and postoperative 5 days(P<0.01),the difference of neutrophils level between before operation and postoperative 5 days was not statistically significant(P>0.05).Conclusions: The clinical curative effects of rectal mucosa columnar ligation injection combined with anal tightening operation on treating rectal prolapse is good,which is worthy of clinical application.