Abstract: Objective:To evaluate the clinical effects of gastrointestinal motility drug combined with microecology on preventing feeding intolerance in premature infants.Methods:Four hundred and forty-eight premature infants were divided into group A(the conventional group,104 cases),group B(the microecological group,173 cases)and group C(the microecological and gastrointestinal motility group,171 cases).Group A were treated with routine nursing and therapy.Based on group A,group B were treated with microecological agent(duplex live bacteria powder of clostridium butyricum and infant bifidobacterium)for 0.5 g twice a day by oral or stomach tube within 6 hours after birth.Based on group B,Mosapride(gastrointestinal motility drug)was given to group C for 0.2 mg/kg three times a day.The incidence of feeding intolerance,decreasing degree of body weight,time of returning to birth weight,reaching full gastrointestinal feeding and hospital stay,and weight growth speed in three groups were investigatedResults:Compared with group A,the incidence of feeding intolerance,duration of feeding intolerance,body weight decreasing extent,time of reaching the birth body weight,full enteral feeding and hospital stay were less in group B and C,their weight growth speed were greater(P0.05 to 0.01).There was no statistically significant difference in the incidence of feeding intolerance between group C and B(P0.05).The time of duration of feeding intolerance returning to birth weight and full gastrointestinal feeding and hospital stay in group C were shorter than those in group B(P0.05 to 0.01).The body weight decreasing extent and weight growth speed in group C were lower and more than those in group B,respectively(P0.01).No adverse reactions were observed in the application process of gastrointestinal motility drug and microecology.Conclusions:Gastrointestinal motility drug combined with microecology can effectively prevent the feeding intolerance of premature infants,the effect is better than singly microecological agent,and can promote the early growth of premature infants and shorten the time of reaching full enteral feeding.