Abstract: Objective:To investigate the value of serum retinol binding protein(srBP)and urinary N-acctyl-glucosaminidase(NAG)in the diagnosis of early-stage nephropathy in type 2 diabetes melitus.Methods:According to the ratio of microalbuminuria(mALB)to urine creatinine(UCr),120 patients with type 2 diabetes were divided into the control group(60 cases,mALB/UCr less than 30 mg/g)and observation group(60 cases,mALB/UCr from 30 to 299 mg/g).The levels of srBP and urinary NAG of all patients were detected.Results:The levels of srBP and urinary NAG and their detection positive rates in observation group were significantly higher than those in control group(P0.01),but the difference of the detection positive rate between the two indicators in observation group had no statistical significance.The levels of srBP and urinary NAG were positively correlated to the levels of urinary mALB in observation group(P0.01).Conclusions:The levels of srBP and urinary NAG can be a sensitive index for identifying the early renal damage of type 2 diabetes,which has important value in the diagnosis of early-stage nephropathy in type 2 diabetes melitus.