Abstract: Objective:To compare the rate of postcholecystectomy syndrome(PCS) followed laparoscopic and open cholecystectomy.Methods:Two hundred and twenty-nine cases of open cholecystectomy and 139 cases of laparoscopic cholecystectomy were retrospectively analyzed for the PCS rate.Results:There was no significant difference between open cholecystectomy and laparoscopic cholecystectomy for the PCS rate(P0.05).The PCS rate was higher in the patients who accepted cholecystectomy during acute phase when compared with non-acute phase(P0.01).Patients underwent T-tube drainage suffered from a much higher PCS rate when compared with other groups(P0.01).Conclusions:There is no significant difference between open cholecystectomy and laparoscopic cholecystectomy for the PCS rate.Patients in the acute phase and underwent T-tube have from a much higher PCS rate.