冠心病患者超敏C反应蛋白、同型半胱氨酸水平与脉搏波传导速度的关系

徐飞; 周勇

冠心病患者超敏C反应蛋白、同型半胱氨酸水平与脉搏波传导速度的关系

徐飞,
周勇

relationship between the plasma level of high sensitivity C creactive protein,homocysteine and pulse wave velocity in patients with coronary heart disease

XU Fei,
ZHOU Yong

摘要

摘要: 目的：探讨冠心病(CHD)患者血浆超敏C反应蛋白(Hs-CrP)、同型半胱氨酸(HCY)水平与脉搏波传导速度(PWV)之间的关系。方法：经冠状动脉造影确诊的57例CHD患者(CHD组)，根据冠状动脉病变支数分为单支病变亚组14例、双支病变亚组26例和多支病变亚组17例；另选25名健康体检者作为对照组。分别检测入选人群的血浆Hs-CrP、HCY水平及PWV；同时检测各组空腹血糖(FPG)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)。结果：与对照组比较，CHD组血浆FPG、TG、TC、LDL-C、Hs-CrP、HCY水平和PWV均明显升高(P0.01)。CHD组各亚组间比较，血浆Hs-CrP、HCY水平和PWV随冠状动脉病变支数的增加而升高，各亚组间差异有统计学意义(P0.05～P0.01)。CHD组Hs-CrP、HCY水平升高与PWV升高均呈正相关关系(P0.05)。结论：血浆Hs-CrP、HCY水平和PWV在CHD患者中明显升高，并与冠状动脉病变程度密切相关，可用于预测动脉粥样硬化的严重程度。

Abstract: Objective:To observe the correlation between the plasma level of high sensitivity C creactive protein(Hs-C P),homocysteine(HCY)and pulse wave velocity(PWV)in patients with coronary heart disease(CHD).Methods:Fifty-seven CHD patients confirmed by coronary angioplasty were divided into single vessel-lesion group(14 cases) double-vessel-lesion group(26 cases)and triple-vessel-lesion group(17 cases),while 25 healthy adults were selected as control.The Hs-CrP,HCY,plasma glucose(FPG),triglyceride(TG) total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)and PWV were detected in each group.Results:Compared with the control,the plasma level of FPG,TG,TC,LDL-C,Hs-CrP,HCY and PWV of the CAD group increased significantly(P0.01).The plasma level of Hs-CrP,HCY and PWV increased in accordance with the number of the coronary lesion(P0.05 to P0.01).The plasma level of HCY was positively correlated with that of Hs-CrP,HCY and PWV(P0.05).Conclusions:The plasma level of Hs-CrP,HCY and PWV are high in patients with CHD and closely correlated with the degree of the coronary lesion,which may be of use in predicting the severity of the CHD.

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