Abstract: Objective:To study the extraction processes of fructus crataegin,ginkgo biloba L and rheum palmatum L of xinnaozhibaoping.Methods:Medicinal materials were extracted with ethanol and the content of anthraquinones were setted as standard.The extraction technology were optimized through orthogonal design.Results:The heating temperature was the main factor of influence extraction effect,followed by extraction time,extraction times and the solvent multiples were the least affect.Six times of 70% ethanol extracting for 3 times(every time for 1.5 hours) at 70 ℃ was the optimum extraction condition.Conclusions:The optimum xinnaozhibaoping extraction from orthogonal design can effectively improve the content of anthraquinones.